Wordpress 2.8.1 was released yesterday and looks like the major reason for upgrading in this case is a new exploit that from my quick reading could be potentially dangerous.  You can find the exploit details here.  Other than that just a standard set of fixes:

• Certain themes were calling get_categories() in such a way that it would fail in 2.8. 2.8.1 works around this so these themes won’t have to change.
• Dashboard memory usage is reduced.  Some people were running out of memory when loading the dashboard, resulting in an incomplete page.
• The automatic upgrade no longer accidentally deletes files when cleaning up from a failed upgrade.
• A problem where the rich text editor wasn’t being loaded due to compression issues has been worked around.
• Extra security has been put in place to better protect you from plugins that do not do explicit permission checks.
• Translation of role names fixed.
• wp_page_menu() defaults to sorting by the user specified menu order rather than the page title.
• Upload error messages are now correctly reported.
• Autosave error experienced by some IE users is fixed.
• Styling glitch in the plugin editor fixed.
• SSH2 filesystem requirements updated.
• Switched back to curl as the default transport.
• Updated the translation library to avoid a problem with mbstring.func_overload.
• Stricter inline style sanitization.
• Stricter menu security.
• Disabled code highlighting due to browser incompatibilities.
• RTL layout fixes.

Full Details at http://wordpress.org/development/2009/07/wordpress-2-8-1/

So I suggest everyone upgrade ASAP to avoid any problems.  I figured I’d make a post just so the word gets out there for anyone stumbling on our blog.